Rbm47 Gene Summary [Mouse]
Enables enzyme-substrate adaptor activity and mRNA 3'-UTR binding activity. Involved in 3'-UTR-mediated mRNA stabilization; cytidine to uridine editing; and positive regulation of interleukin-10 production. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in nucleus. Is expressed in several structures, including brain ventricle and choroid plexus; genitourinary system; gut; sensory organ; and yolk sac. Orthologous to human RBM47 (RNA binding motif protein 47). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbm47 |
| Official Name | RNA binding motif protein 47 [Source:MGI Symbol;Acc:MGI:2384294] |
| Ensembl ID | ENSMUSG00000070780 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein 47 |
| Synonyms | 9530077J19Rik, FLJ20273, NET18, RGD1359713, RNA binding motif protein 47 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbm47 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- polyadenylate binding protein, human types 1, 2, 3, 4 family
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- protein binding activity, bridging
- enzyme binding
- protein binding
- heterogeneous nuclear ribonucleoprotein R, Q family
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypertension
- tumorigenesis
- organismal death
- acute lung injury
- dextran sodium sulfate-induced colitis
- lipopolysaccharide induced acute lung injury
- colorectal cancer
- brain infarction
- renal cell carcinoma
role in cell
- expression in
- migration
- proliferation
- invasion by
- cellular infiltration by
- differentiation
- sunitinib sensitivity
- alternative splicing by
- stabilization in
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbm47 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-UTR-mediated mRNA stabilization
- RNA splicing
- regulation of alternative nuclear mRNA splicing, via spliceosome
- positive regulation of type I interferon-mediated signaling pathway
- mRNA processing
- positive regulation of interleukin-10 production
- cytidine to uridine editing
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- apolipoprotein B mRNA editing enzyme complex
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- mRNA 3'-UTR binding
- enzyme binding