Npepps Gene Summary [Mouse]
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in cellular response to hypoxia; peptide catabolic process; and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and integumental system. Orthologous to human NPEPPS (aminopeptidase puromycin sensitive). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npepps |
| Official Name | aminopeptidase puromycin sensitive [Source:MGI Symbol;Acc:MGI:1101358] |
| Ensembl ID | ENSMUSG00000001441 |
| Bio databases IDs | |
| Aliases | aminopeptidase puromycin sensitive |
| Synonyms | AAP-S, aminopeptidase puromycin sensitive, goku, MP100, PSA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Npepps often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase M1 N-terminal domain
- Peptidase family M1 domain
- ERAP1-like C-terminal domain
- peptidase
- aminopeptidase
- peptidase GluZincin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- open-angle glaucoma
- multiple sclerosis
- uterine leiomyoma
- leiomyomatosis
- morbid obesity
regulates
- Nucleoprotein
- NPEPPS
- MHC I (complex)
role in cell
- differentiation
- morphology
- dipeptide repeat protein sensitivity
- response by
- lipotoxicity in
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptosomal membrane fractions
- cell surface
- perinuclear region
- Nucleus
- cytoplasmic particles
- cytosol
- synapse
- perikaryon
- dendrites
- postsynaptic density
- presynaptic terminals
- parallel fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Npepps gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptide catabolic process
- protein polyubiquitination
- proteolysis
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloaminopeptidase activity
- aminopeptidase activity
- peptide binding