Tcf25 Gene Summary [Mouse]
Predicted to enable DNA binding activity and transcription corepressor activity. Predicted to be involved in regulation of protein K48-linked ubiquitination and rescue of stalled ribosome. Located in nucleus. Is expressed in several structures, including alimentary system; bone; genitourinary system; nervous system; and skin. Orthologous to human TCF25 (TCF25 ribosome quality control complex subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcf25 |
| Official Name | transcription factor 25 (basic helix-loop-helix) [Source:MGI Symbol;Acc:MGI:1914105] |
| Ensembl ID | ENSMUSG00000001472 |
| Bio databases IDs | |
| Aliases | transcription factor 25 (basic helix-loop-helix) |
| Synonyms | 1100001J13Rik, 1810041K11Rik, D8Ertd325e, FKSG26, hKIAA1049, Hulp1, KIAA1049, mKIAA1049, NULP1, PRO2620, RGD1309054, TCF25 ribosome quality control complex subunit, transcription factor 25 (basic helix-loop-helix) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcf25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Transcriptional repressor TCF25
- protein binding
Pathways
Biological processes and signaling networks where the Tcf25 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- myocardial fibrosis
- epithelial basal cell carcinoma
- heart failure
- pressure overload hypertrophy
- cardiac hypertrophy
role in cell
- cohesion in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcf25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- rescue of stalled ribosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription corepressor activity