Klhl10 Gene Summary [Mouse]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Acts upstream of or within several processes, including homeostasis of number of cells within a tissue; reproductive structure development; and spermatid development. Located in cytoplasm. Is expressed in alimentary system and male reproductive gland or organ. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Orthologous to human KLHL10 (kelch like family member 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl10 |
| Official Name | kelch-like 10 [Source:MGI Symbol;Acc:MGI:2181067] |
| Ensembl ID | ENSMUSG00000001558 |
| Bio databases IDs | |
| Aliases | kelch-like 10 |
| Synonyms | 4921517C11Rik, kelch-like 10, kelch-like family member 10, SPGF11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male genitalia morphogenesis
- male gonad development
- homeostasis of number of cells within a tissue
- spermatid development
- cell morphogenesis
- fertilization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding