KLHL10 Gene Summary [Human]
The protein encoded by this gene belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain a BACK domain and six C-terminal kelch repeats. Kelch domains are thought to form a four stranded beta-sheet blade structure that can fold into a beta-propeller domain when multiple kelch repeats are found together. Mutations in this gene have been associated with oligozoospermia in some infertile males. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | KLHL10 |
| Official Name | kelch like family member 10 [Source:HGNC Symbol;Acc:HGNC:18829] |
| Ensembl ID | ENSG00000161594 |
| Bio databases IDs | |
| Aliases | kelch like family member 10 |
| Synonyms | 4921517C11Rik, kelch-like 10, kelch-like family member 10, SPGF11 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLHL10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLHL10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male genitalia morphogenesis
- male gonad development
- homeostasis of number of cells within a tissue
- spermatid development
- cell morphogenesis
- fertilization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding