Gps1 Gene Summary [Mouse]
Predicted to be involved in protein deneddylation. Part of COP9 signalosome. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human GPS1 (G protein pathway suppressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Gps1 |
| Official Name | G protein pathway suppressor 1 [Source:MGI Symbol;Acc:MGI:2384801] |
| Ensembl ID | ENSMUSG00000025156 |
| Bio databases IDs | |
| Aliases | G protein pathway suppressor 1 |
| Synonyms | COPS1, CSN1, G protein pathway suppressor 1, MFH, SGN1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gps1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- GTPase inhibitor
- protein binding
- 26S proteasome subunit RPN7
Pathways
Biological processes and signaling networks where the Gps1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- cutaneous melanoma cancer
- placental cancer
role in cell
- expression in
- phosphorylation in
- degradation in
- crizotinib sensitivity
- homologous recombination in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gps1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deneddylation
- protein neddylation
- JNK cascade
- regulation of protein neddylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- signalosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase inhibitor activity