Fam98a Gene Summary [Mouse]
Predicted to enable protein methyltransferase activity. Involved in lysosome localization and positive regulation of ruffle assembly. Predicted to be part of tRNA-splicing ligase complex. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human FAM98A (family with sequence similarity 98 member A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam98a |
| Official Name | family with sequence similarity 98, member A [Source:MGI Symbol;Acc:MGI:1919972] |
| Ensembl ID | ENSMUSG00000002017 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 98, member A |
| Synonyms | 2810405J04Rik, family with sequence similarity 98 member A, family with sequence similarity 98, member A, RGD1305486 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fam98a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein methyltransferase
- Protein of unknown function (DUF2465)
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fam98a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome localization
- positive regulation of gene expression
- positive regulation of cell proliferation
- tRNA splicing, via endonucleolytic cleavage and ligation
- positive regulation of ruffle assembly
- protein methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- tRNA-splicing ligase complex
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- protein methyltransferase activity