Supt6 Gene Summary [Mouse]
Predicted to enable histone binding activity and nucleosome binding activity. Involved in several processes, including regulation of mRNA export from nucleus; regulation of nucleobase-containing compound metabolic process; and transcription elongation-coupled chromatin remodeling. Acts upstream of or within blastocyst formation. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; retina; and spleen. Orthologous to human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Supt6 |
| Official Name | SPT6, histone chaperone and transcription elongation factor [Source:MGI Symbol;Acc:MGI:107726] |
| Ensembl ID | ENSMUSG00000002052 |
| Bio databases IDs | |
| Aliases | SPT6, histone chaperone and transcription elongation factor |
| Synonyms | 5131400N11RIK, emb-5, mKIAA0162, SPT6, SPT6H, SPT6, histone chaperone and transcription elongation factor, SPT6 homolog, histone chaperone and transcription elongation factor, SPTH6, Supt6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Supt6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HHH domain
- Crossover junction endodeoxyribonuclease RuvC and similar proteins
- histone binding
- Helix-hairpin-helix domain
- transcription regulator
- Src homology 2 (SH2) domain
- protein binding
- Helix-hairpin-helix motif
- SH2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
regulates
role in cell
- cell death
- replication in
- differentiation
- somatic hypermutation in
- reactivation in
- class switching in
- homologous recombination in
- modulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Supt6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- regulation of muscle cell differentiation
- nucleosome organization
- RNA splicing
- regulation of mRNA processing
- blastocyst formation
- mRNA processing
- regulation of isotype switching
- regulation of mRNA export from nucleus
- mRNA transport
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription elongation factor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- histone binding
- nucleosome binding