Aicda Gene Summary [Mouse]
Enables cytidine deaminase activity. Involved in cytidine deamination and isotype switching. Acts upstream of or within cellular response to lipopolysaccharide and defense response to bacterium. Predicted to be located in nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in P-body and nucleus. Is expressed in several structures, including immune system; lower urogenital tract; lung; reproductive system; and urethra epithelium. Used to study immunodeficiency with hyper-IgM type 2. Human ortholog(s) of this gene implicated in hyperimmunoglobulin syndrome and immunodeficiency with hyper-IgM type 2. Orthologous to human AICDA (activation induced cytidine deaminase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aicda |
| Official Name | activation-induced cytidine deaminase [Source:MGI Symbol;Acc:MGI:1342279] |
| Ensembl ID | ENSMUSG00000040627 |
| Bio databases IDs | |
| Aliases | activation-induced cytidine deaminase |
| Synonyms | ACTIVATION-INDUCED ADENOSINE DEAMINASE, Activation-Induced Cytidine Deaminase, AID, ARP2, CDA2, HEL-S-284, HIGM2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aicda often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- APOBEC2
- cytidine_deaminase-like
- ubiquitin protein ligase binding
- nuclear export signal
- APOBEC-like N-terminal domain
- enzyme
- protein binding
- APOBEC1
- identical protein binding
- Secreted Novel AID/APOBEC-like Deaminase 4
- APOBEC3
- deoxycytidine deaminase
- cytidine deaminase
- Novel AID APOBEC clade 2
- Novel AID APOBEC clade 1
- APOBEC4
Pathways
Biological processes and signaling networks where the Aicda gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- neoplasia
- hyper-IgM syndrome type 2
- hematological neoplasia
- acinar to ductal metaplasia
- lymphomagenesis
- tumorigenesis
- early-onset preeclampsia
- chronic lymphocytic leukemia
- cancer
role in cell
- expression in
- proliferation
- quantity
- number
- loss
- response
- development
- survival
- expansion
- induction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aicda gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of retroviral genome replication
- B cell differentiation
- regulation of DNA replication involved in S phase
- cytidine deamination
- mRNA processing
- hypomethylation of CpG island
- defense response to bacterium
- DNA cytosine deamination
- cellular response to lipopolysaccharide
- defense response to virus
- cytidine to uridine editing
- somatic diversification of immunoglobulins
- somatic hypermutation of immunoglobulin genes
- isotype switching
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- cytoplasmic mRNA processing body
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- RNA binding
- cytidine deaminase activity