Supt6h Gene Summary [Rat]
Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in several processes, including chromatin remodeling; regulation of mRNA export from nucleus; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within blastocyst formation. Predicted to be part of transcription elongation factor complex. Orthologous to human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Supt6h |
| Official Name | SPT6 homolog, histone chaperone and transcription elongation factor [Source:RGD Symbol;Acc:1309290] |
| Ensembl ID | ENSRNOG00000012240 |
| Bio databases IDs | |
| Aliases | SPT6 homolog, histone chaperone and transcription elongation factor |
| Synonyms | 5131400N11RIK, emb-5, mKIAA0162, SPT6, SPT6H, SPT6, histone chaperone and transcription elongation factor, SPT6 homolog, histone chaperone and transcription elongation factor, SPTH6, Supt6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Supt6h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HHH domain
- Crossover junction endodeoxyribonuclease RuvC and similar proteins
- histone binding
- Helix-hairpin-helix domain
- transcription regulator
- Src homology 2 (SH2) domain
- protein binding
- Helix-hairpin-helix motif
- SH2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
regulates
role in cell
- cell death
- replication in
- differentiation
- somatic hypermutation in
- reactivation in
- class switching in
- homologous recombination in
- modulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Supt6h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- regulation of muscle cell differentiation
- nucleosome organization
- RNA splicing
- regulation of mRNA processing
- blastocyst formation
- mRNA processing
- regulation of isotype switching
- regulation of mRNA export from nucleus
- mRNA transport
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription elongation factor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- histone binding
- nucleosome binding