Inpp5j Gene Summary [Mouse]

Enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity. Acts upstream of or within negative regulation of neuron projection development and negative regulation of peptidyl-serine phosphorylation. Located in dendritic shaft; growth cone; and plasma membrane. Is expressed in alimentary system; ear; nervous system; respiratory system; and skeleton. Orthologous to human INPP5J (inositol polyphosphate-5-phosphatase J). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Inpp5j
Official Name
inositol polyphosphate 5-phosphatase J [Source:MGI Symbol;Acc:MGI:2158663]
Ensembl ID
ENSMUSG00000034570
Bio databases IDs NCBI: 170835 Ensembl: ENSMUSG00000034570
Aliases inositol polyphosphate 5-phosphatase J
Synonyms Image:4164282, inositol polyphosphate-5-phosphatase J, Inpp, INPP5, PIB5PA, PIPP
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Inpp5j often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Family of unknown function (DUF5585)
  • SKICH domain
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
  • inositol-polyphosphate 5-phosphatase
  • Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
  • phosphatase
  • protein binding
  • phosphoinositide 5-phosphatase

Pathways

Biological processes and signaling networks where the Inpp5j gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • breast carcinoma
  • cervical cancer
  • epithelial uterine cancer
  • cervical small cell carcinoma
  • extrapulmonary small cell cancer
regulated by
  • trans-hydroxytamoxifen
  • beta-estradiol
  • Immunoglobulin
  • PPARGC1A
  • butyric acid
  • mir-223
  • raloxifene
  • ganglioside
  • ALOX5
  • INPP5F
regulates
  • 1,4,5-IP3
  • phosphatidylinositol
  • 1,3,4,5-IP4
  • actin
  • inositol phosphate
  • peptide
  • alpha actin
role in cell
  • survival
  • development
  • polymerization
  • disassembly

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • ruffle
  • Cytoplasm
  • cell periphery
  • cytosol
  • membrane ruffles
  • growth cone
  • dendritic shafts

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Inpp5j gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • inositol phosphate metabolic process
  • negative regulation of neuron projection development
  • negative regulation of peptidyl-serine phosphorylation
  • phosphatidylinositol biosynthetic process
  • phosphatidylinositol dephosphorylation

Cellular Component

Where in the cell the gene product is active
  • growth cone
  • cytoplasm
  • dendritic shaft
  • ruffle
  • cytosol
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
  • SH3 domain binding
  • inositol-1,4,5-trisphosphate 5-phosphatase activity
  • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
  • inositol-polyphosphate 5-phosphatase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.