Bicd1 Gene Summary [Mouse]
Enables proteinase activated receptor binding activity. Involved in microtubule anchoring at microtubule organizing center; negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; and stress granule assembly. Predicted to be located in several cellular components, including centrosome; perinuclear region of cytoplasm; and trans-Golgi network. Predicted to be active in Golgi apparatus and cytosol. Predicted to colocalize with cytoplasmic microtubule. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human BICD1 (BICD cargo adaptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Bicd1 |
| Official Name | BICD cargo adaptor 1 [Source:MGI Symbol;Acc:MGI:1101760] |
| Ensembl ID | ENSMUSG00000003452 |
| Bio databases IDs | |
| Aliases | BICD cargo adaptor 1 |
| Synonyms | B830009D06RIK, BICD, BICD cargo adaptor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bicd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- protein kinase binding
- cytoskeletal protein binding
- structural constituent of cytoskeleton
- G-protein-coupled receptor binding
- dynein intermediate chain binding
- enzyme binding
- protein binding
- Microtubule-associated protein Bicaudal-D
- cytoskeletal adaptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- pancreatic epithelial cancer
- pancreatic carcinoma
- rotator cuff injury
- pulmonary emphysema
regulated by
- beta-estradiol
- SMARCB1
- pyridaben
- LY294002
- paraquat
- mir-122 (includes others)
- maneb
role in cell
- proliferation
- assembly
- endocytosis by
- organization
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- centrosome
- Golgi Apparatus
- cytosol
- trans Golgi network
- cytoplasmic vesicles
- secretory vesicles
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bicd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stress granule assembly
- regulation of microtubule cytoskeleton organization
- intracellular mRNA localization
- regulation of proteinase activated receptor activity
- anatomical structure morphogenesis
- RNA processing
- minus-end-directed organelle transport along microtubule
- negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
- microtubule anchoring at microtubule organizing center
- viral reproduction
- protein localization to organelle
- positive regulation of receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- centrosome
- trans-Golgi network
- perinuclear region of cytoplasm
- cytoskeleton
- membrane
- cytoplasmic vesicle
- cytosol
- Golgi apparatus
- cytoplasmic microtubule
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- cytoskeletal adaptor activity
- protein binding
- dynactin binding
- proteinase activated receptor binding
- small GTPase binding
- structural constituent of cytoskeleton
- dynein complex binding
- dynein intermediate chain binding