Nedd1 Gene Summary [Mouse]
Predicted to enable gamma-tubulin binding activity. Predicted to be involved in microtubule nucleation and mitotic cell cycle. Predicted to act upstream of or within microtubule depolymerization and regulation of establishment of protein localization. Located in apical part of cell; cytoplasm; and microtubule cytoskeleton. Is expressed in several structures, including duodenum epithelium; genitourinary system; lung; nervous system; and sensory organ. Orthologous to human NEDD1 (NEDD1 gamma-tubulin ring complex targeting factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nedd1 |
| Official Name | neural precursor cell expressed, developmentally down-regulated gene 1 [Source:MGI Symbol;Acc:MGI:97293] |
| Ensembl ID | ENSMUSG00000019988 |
| Bio databases IDs | |
| Aliases | neural precursor cell expressed, developmentally down-regulated gene 1 |
| Synonyms | GCP-WD, NEDD1 gamma-tubulin ring complex targeting factor, NEDD1 γ-tubulin ring complex targeting factor, neural precursor cell expressed, developmentally down-regulated gene 1, TUBGCP7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nedd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- ligand-binding domain
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- formation in
- binding in
- formation
- morphology
- depolymerization
- interaction in
- interaction
- duplication
- nucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- apical compartment
- basal bodies
- centrosome
- centriole
- cytosol
- nucleoplasm
- spindle pole
- spindle fibers
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nedd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- microtubule nucleation
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- pericentriolar material
- centrosome
- apical part of cell
- centriole
- cilium basal body
- spindle pole
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- gamma-tubulin binding