Spata2 Gene Summary [Mouse]
Predicted to enable signaling receptor complex adaptor activity and ubiquitin-specific protease binding activity. Involved in protein linear deubiquitination; regulation of necroptotic process; and regulation of tumor necrosis factor-mediated signaling pathway. Acts upstream of or within seminiferous tubule development and spermatogenesis. Located in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human SPATA2 (spermatogenesis associated 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spata2 |
| Official Name | spermatogenesis associated 2 [Source:MGI Symbol;Acc:MGI:2146885] |
| Ensembl ID | ENSMUSG00000047030 |
| Bio databases IDs | |
| Aliases | spermatogenesis associated 2 |
| Synonyms | mKIAA0757, PD1, PPP1R145, spermatogenesis associated 2, tamo |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spata2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- B-box-type zinc finger superfamily
- binding protein
- protease binding
- receptor signaling complex scaffold protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
role in cell
- expression in
- cell death
- activation in
- apoptosis
- phosphorylation in
- binding in
- degradation in
- recruitment
- production in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- fibrillar center
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spata2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- necroptosis
- seminiferous tubule development
- spermatogenesis
- regulation of tumor necrosis factor-mediated signaling pathway
- regulation of inflammatory response
- regulation of necroptosis
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor signaling complex scaffold activity