Ier3 Gene Summary [Mouse]
Acts upstream of or within several processes, including intracellular signal transduction; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and regulation of primary metabolic process. Located in nucleus. Is expressed in brain; future forebrain; head; and placenta. Human ortholog(s) of this gene implicated in T-cell non-Hodgkin lymphoma. Orthologous to human IER3 (immediate early response 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ier3 |
| Official Name | immediate early response 3 [Source:MGI Symbol;Acc:MGI:104814] |
| Ensembl ID | ENSMUSG00000003541 |
| Bio databases IDs | |
| Aliases | immediate early response 3 |
| Synonyms | cI-3, DIF-2, GLY96, IEX-1, IEX-1L, immediate early response 3, Ler3, PRG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ier3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nuclear localization sequence
- protein binding
- fxfp sequence
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- non-Hodgkin disease
- cervical cancer
- cancer
- lymphomagenesis
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
- adenoma formation
role in cell
- growth
- phosphorylation in
- expression in
- apoptosis
- cell death
- survival
- proliferation
- quantity
- G2/M phase
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ier3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- negative regulation of inflammatory response
- regulation of DNA repair
- glycolysis
- negative regulation of systemic arterial blood pressure
- negative regulation of glycolysis
- positive regulation of protein catabolic process
- DNA damage response, signal transduction resulting in induction of apoptosis
- anatomical structure morphogenesis
- response to DNA damage stimulus
- regulation of nucleocytoplasmic transport
- response to protozoan
- negative regulation of apoptotic process
- apoptotic process
- regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding