Ppp2r5c Gene Summary [Mouse]
Predicted to enable protein phosphatase activator activity. Predicted to be involved in meiotic sister chromatid cohesion; negative regulation of cell population proliferation; and signal transduction by p53 class mediator. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in Golgi apparatus; chromosome, centromeric region; and nucleoplasm. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp2r5c |
| Official Name | protein phosphatase 2, regulatory subunit B', gamma [Source:MGI Symbol;Acc:MGI:1349475] |
| Ensembl ID | ENSMUSG00000017843 |
| Bio databases IDs | |
| Aliases | protein phosphatase 2, regulatory subunit B', gamma |
| Synonyms | 2610043M05RIK, 2700063L20Rik, AW545884, B56G, B56gamma, B56 Gamma3, D12Bwg0916e, LOC100040799, LOC102557581, LOC684586, PP2A B' gamma, PP2A B' γ, PR61G, Pr61 γ, protein phosphatase 2 regulatory subunit B'gamma, protein phosphatase 2, regulatory subunit B', gamma, protein phosphatase 2 regulatory subunit B'γ, protein phosphatase 2, regulatory subunit B', γ, RGD1564600 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp2r5c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- protein phosphatase regulator
- Protein phosphatase 2A regulatory B subunit (B56 family)
- protein binding
Pathways
Biological processes and signaling networks where the Ppp2r5c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Autophagy
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Ceramide Signaling
- Cyclins and Cell Cycle Regulation
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- ILK Signaling
- Mitotic Roles of Polo-Like Kinase
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of eIF4 and p70S6K Signaling
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of Tissue Factor in Cancer
- Telomerase Signaling
- Tight Junction Signaling
- WNT/β-catenin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- restless legs syndrome
- organismal death
- non-small cell lung carcinoma
- non-small cell lung cancer
- metastasis
- neoplastic cell transformation
- mental retardation
- autism
- vitiligo
role in cell
- phosphorylation in
- binding in
- expression in
- migration
- motility
- proliferation
- survival
- growth
- 5-fluorouracil sensitivity
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi-enriched fraction
- Cytoplasm
- cell periphery
- cellular membrane
- focal adhesions
- Golgi Apparatus
- cytosol
- Golgi membrane
- nucleoplasm
- Z line
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp2r5c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- signal transduction
- negative regulation of cell proliferation
- protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- Golgi apparatus
- protein phosphatase type 2A complex
- chromosome, centromeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase activator activity
- protein phosphatase regulator activity