Mcl1 Gene Summary [Mouse]
Enables BH3 domain binding activity. Involved in extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of apoptotic process; and positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; blastocyst; central nervous system; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung cancer; and lung non-small cell carcinoma. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcl1 |
| Official Name | myeloid cell leukemia sequence 1 [Source:MGI Symbol;Acc:MGI:101769] |
| Ensembl ID | ENSMUSG00000038612 |
| Bio databases IDs | |
| Aliases | myeloid cell leukemia sequence 1 |
| Synonyms | BCL2L3, EAT, Gm52627, MCL1 apoptosis regulator, BCL2 family member, mcl1/EAT, myeloid cell leukaemia sequence 1, myeloid cell leukemia sequence 1, TM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mcl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bcl-2_like
- protein carrier
- protein dimerization
- mitochondrial presequence
- GSK3 beta phosphorylation site
- caspase cleavage site
- protein domain specific binding
- protein binding
- phosphorylation site
- PEST domain
- BH3 binding domain
- binding protein
- Bcl-2 homology 1 domain
- Bcl-2 homology 2 domain
- Caspase 3 cleavage site
- Bcl-2 homology 3 domain
- ubiquitination site
- transmembrane domain
- loop domain
- protein heterodimerization
- transporter
Pathways
Biological processes and signaling networks where the Mcl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- liver cancer
- liver cholangiocarcinoma
- colorectal cancer
- neoplasia
- squamous cell lung cancer
- non-small cell lung cancer
- Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
role in cell
- growth
- phosphorylation in
- expression in
- production in
- cell death
- proliferation
- apoptosis
- cell viability
- differentiation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum fraction
- membrane fraction
- mitochondrial fraction
- intracellular space
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- outer leaflet
- mitochondrial membrane
- mitochondrial outer membrane
- nucleoplasm
- mitoplasts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mcl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein transmembrane transport
- response to cytokine stimulus
- cellular homeostasis
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- mitochondrial fusion
- DNA damage response, signal transduction resulting in induction of apoptosis
- extrinsic apoptotic signaling pathway in absence of ligand
- response to DNA damage stimulus
- negative regulation of anoikis
- negative regulation of autophagy
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- release of cytochrome c from mitochondria
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- cell fate determination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Bcl-2 family protein complex
- membrane
- mitochondrion
- cytosol
- mitochondrial outer membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- BH domain binding
- BH3 domain binding
- channel activity
- protein binding
- protein transmembrane transporter activity
- protein heterodimerization activity