Aven Gene Summary [Mouse]
Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of apoptotic process. Predicted to be located in membrane. Is expressed in several structures, including heart; liver; metanephros; spleen; and testis. Orthologous to human AVEN (apoptosis and caspase activation inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aven |
| Official Name | apoptosis, caspase activation inhibitor [Source:MGI Symbol;Acc:MGI:1921518] |
| Ensembl ID | ENSMUSG00000003604 |
| Bio databases IDs | |
| Aliases | apoptosis, caspase activation inhibitor |
| Synonyms | 1700013A01Rik, 1700056A21RIK, apoptosis and caspase activation inhibitor, apoptosis, caspase activation inhibitor, mAven-L, mAven-S, PDCD12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aven often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membranes
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aven gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- apoptotic process
- negative regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- endomembrane system
Molecular Function
What the gene product does at the molecular level
- protein binding