Man1a Gene Summary [Mouse]
Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in mannose trimming involved in glycoprotein ERAD pathway and protein targeting to ER. Located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb mesenchyme; and sensory organ. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Man1a |
| Official Name | mannosidase 1, alpha [Source:MGI Symbol;Acc:MGI:104677] |
| Ensembl ID | ENSMUSG00000003746 |
| Bio databases IDs | |
| Aliases | mannosidase 1, alpha |
| Synonyms | Aa2-166, HUMM3, HUMM9, Man1a, MAN9, mannosidase 1, alpha, mannosidase 1, α, mannosidase alpha class 1A member 1, mannosidase, alpha, class 1A, member 1, mannosidase α class 1A member 1, mannosidase, α, class 1A, member 1, PCR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Man1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolase family 47
- mannosidase
- mannosyl-oligosaccharide 1,2-alpha-mannosidase
- calcium ion binding
- Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cytosol
- Golgi membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Man1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- protein glycosylation
- protein targeting to ER
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- cytosol
- cytoplasmic vesicle
- Golgi apparatus
- endoplasmic reticulum
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
- mannosidase activity