MAN1A1 Gene Summary [Human]
This gene encodes a class I mammalian Golgi 1,2-mannosidase which is a type II transmembrane protein. This protein catalyzes the hydrolysis of three terminal mannose residues from peptide-bound Man(9)-GlcNAc(2) oligosaccharides and belongs to family 47 of glycosyl hydrolases. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | MAN1A1 |
| Official Name | mannosidase alpha class 1A member 1 [Source:HGNC Symbol;Acc:HGNC:6821] |
| Ensembl ID | ENSG00000111885 |
| Bio databases IDs | |
| Aliases | mannosidase alpha class 1A member 1 |
| Synonyms | Aa2-166, HUMM3, HUMM9, Man1a, MAN9, mannosidase 1, alpha, mannosidase 1, α, mannosidase alpha class 1A member 1, mannosidase, alpha, class 1A, member 1, mannosidase α class 1A member 1, mannosidase, α, class 1A, member 1, PCR1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAN1A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyl hydrolase family 47
- mannosidase
- mannosyl-oligosaccharide 1,2-alpha-mannosidase
- calcium ion binding
- Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- cytosol
- Golgi membrane
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAN1A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- protein glycosylation
- protein targeting to ER
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- cytosol
- cytoplasmic vesicle
- Golgi apparatus
- endoplasmic reticulum
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
- mannosidase activity