Brinp2 Gene Summary [Mouse]
Involved in cellular response to retinoic acid; central nervous system neuron differentiation; and negative regulation of mitotic cell cycle. Acts upstream of or within locomotion and nervous system development. Predicted to be located in extracellular region. Predicted to be active in cytoplasm; dendrite; and neuronal cell body. Is expressed in cortical antihem and cortical plate. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human BRINP2 (BMP/retinoic acid inducible neural specific 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Brinp2 |
| Official Name | bone morphogenic protein/retinoic acid inducible neural-specific 2 [Source:MGI Symbol;Acc:MGI:2443333] |
| Ensembl ID | ENSMUSG00000004031 |
| Bio databases IDs | |
| Aliases | bone morphogenic protein/retinoic acid inducible neural-specific 2 |
| Synonyms | 6430517E21Rik, BMP/retinoic acid inducible neural specific 2, bone morphogenic protein/retinoic acid inducible neural-specific 2, DBCCR1L2, FAM5B, mKIAA1747 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brinp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BMP/retinoic acid-inducible neural-specific protein
- membrane-attack complex / perforin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brinp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to retinoic acid
- nervous system development
- negative regulation of mitotic cell cycle
- positive regulation of neuron differentiation
- central nervous system neuron differentiation
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- neuronal cell body
- extracellular region