Tbc1d15 Gene Summary [Mouse]
Enables GTPase activator activity. Located in cytoplasm and extracellular region. Is expressed in brain; embryo; liver; spleen; and thymus. Orthologous to human TBC1D15 (TBC1 domain family member 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tbc1d15 |
| Official Name | TBC1 domain family, member 15 [Source:MGI Symbol;Acc:MGI:1913937] |
| Ensembl ID | ENSMUSG00000020130 |
| Bio databases IDs | |
| Aliases | TBC1 domain family, member 15 |
| Synonyms | 4432405K22RIK, LY6DL, RAB7-GAP, TBC1 domain family member 15, TBC1 domain family, member 15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tbc1d15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab-GTPase-TBC domain
- Rab-binding domain (RBD)
- Domain in Tre-2, BUB2p, and Cdc16p
- GTPase activator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- myasthenia gravis
regulated by
- GH1
- eptifibatide
- 1-methyl-4-phenylpyridinium
- collagen-related peptide
- glucocorticoid
- cannabinol
- indomethacin
role in cell
- cell death
- formation
- fragmentation in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tbc1d15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity