Sf3b6 Gene Summary [Mouse]
Predicted to enable mRNA binding activity. Acts upstream of or within blastocyst formation and mRNA splicing, via spliceosome. Located in nucleus. Is expressed in central nervous system; early conceptus; secondary oocyte; and sensory organ. Orthologous to human SF3B6 (splicing factor 3b subunit 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sf3b6 |
| Official Name | splicing factor 3B, subunit 6 [Source:MGI Symbol;Acc:MGI:1913305] |
| Ensembl ID | ENSMUSG00000037361 |
| Bio databases IDs | |
| Aliases | splicing factor 3B, subunit 6 |
| Synonyms | 0610009D07Rik, 6030419K15Rik, CGI-110, HSPC175, Ht006, P14, SAP14, SAP14a, Sap14/Sf3b, SF3B14, SF3B14a, splicing factor 3b subunit 6, splicing factor 3B, subunit 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sf3b6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- spliceosomes
- nucleoplasm
- interchromatin granule clusters
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sf3b6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- blastocyst formation
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- U12-type spliceosomal complex
- nucleus
- catalytic step 2 spliceosome
- precatalytic spliceosome
- spliceosomal complex
- U2-type spliceosomal complex
- U2 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding