Slc1a2 Gene Summary [Mouse]
Enables cysteine transmembrane transporter activity; high-affinity L-glutamate transmembrane transporter activity; and monoatomic anion transmembrane transporter activity. Involved in several processes, including L-glutamate import across plasma membrane; cellular response to cocaine; and glutathione biosynthetic process. Acts upstream of or within several processes, including L-glutamate transmembrane transport; monoatomic anion transmembrane transport; and positive regulation of D-glucose import. Located in several cellular components, including astrocyte projection; axolemma; and membrane raft. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc1a2 |
| Official Name | solute carrier family 1 (glial high affinity glutamate transporter), member 2 [Source:MGI Symbol;Acc:MGI:101931] |
| Ensembl ID | ENSMUSG00000005089 |
| Bio databases IDs | |
| Aliases | solute carrier family 1 (glial high affinity glutamate transporter), member 2 |
| Synonyms | 1700091C19Rik, 2900019G14RIK, DEE41, EAAT2, EIEE41, Glt, GLT-1, Glutamate-aspartate transporter, HBGT, MGLT1, solute carrier family 1 (glial high affinity glutamate transporter), member 2, solute carrier family 1 member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc1a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium:dicarboxylate symporter family
- sulfur amino acid transporter
- glutamate:sodium symporter
- protein binding
- high-affinity glutamate transporter
- neutral amino acid transporter
- anion transporter
- organic cation transporter
- glutamate transporter
- N-linked glycosylation site
- TcyP
- C-terminal extension
- transporter
Pathways
Biological processes and signaling networks where the Slc1a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- amyotrophic lateral sclerosis
- seizures
- hepatocellular carcinoma
- non-insulin-dependent diabetes mellitus
- stroke
- liver cancer
- epithelial cancer
- spinocerebellar ataxia type 7
- myositis
regulates
- Na+
- cholesterol
- adenosine triphosphate
- L-glutamic acid
- SLC1A2
- glutathione
- K+
- ion
- amino acids
- glutamate receptor
role in cell
- cell death
- production in
- proliferation
- function
- damage in
- uptake in
- loss
- depolarization
- depolarization in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- cellular membrane
- vesicles
- Mitochondria
- presynaptic membrane
- dendritic spines
- axonal membrane
- nerve ending
- nodal axolemma
- synapse
- membrane rafts
- detergent insoluble microdomains
- membrane processes
- perikaryon
- axons
- dendritic shafts
- astrocyte projections
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc1a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- telencephalon development
- response to wounding
- response to amino acid stimulus
- glutathione biosynthetic process
- positive regulation of glucose import
- synaptic transmission
- response to xenobiotic stimulus
- visual behavior
- neurotransmitter transport
- ion transport
- cellular response to cocaine
- transepithelial transport
- L-glutamate transport
- protein homotrimerization
- D-aspartate import
- adult behavior
- L-aspartate transport
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- membrane raft
- membrane
- cell body
- vesicle
- axolemma
- neuron projection terminus
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- neutral amino acid transmembrane transporter activity
- anion transmembrane transporter activity
- cysteine transmembrane transporter activity
- high-affinity glutamate transmembrane transporter activity
- glutamate:sodium symporter activity
- L-glutamate transmembrane transporter activity