Hmg20a Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of protein sumoylation; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including axial skeleton; early conceptus; genitourinary system; gut; and nervous system. Orthologous to human HMG20A (high mobility group 20A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmg20a |
| Official Name | high mobility group 20A [Source:MGI Symbol;Acc:MGI:1914117] |
| Ensembl ID | ENSMUSG00000032329 |
| Bio databases IDs | |
| Aliases | high mobility group 20A |
| Synonyms | 1200004E06Rik, 5730490E10Rik, high mobility group 20A, HM20A, HMGX1, HMGXB1, iBRAF, RGD1564760 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hmg20a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- HMG-box domain
- high mobility group
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- diabetes mellitus
- nephrosis
- diabetic retinopathy
- diabetic neuropathy
role in cell
- expression in
- invasion by
- proliferation
- motility
- differentiation
- cisplatin sensitivity
- invasiveness
- binding in
- DNA damage repair in
- sumoylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hmg20a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of neuron differentiation
- regulation of gene expression
- regulation of transcription, DNA-dependent
- negative regulation of protein sumoylation
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding