Ina Gene Summary [Mouse]
A structural constituent of postsynaptic intermediate filament cytoskeleton. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within cellular response to leukemia inhibitory factor and neurofilament cytoskeleton organization. Located in neurofilament. Is active in Schaffer collateral - CA1 synapse and postsynapse. Is expressed in several structures, including central nervous system; gut; peripheral nervous system ganglion; sensory organ; and trigeminal nerve. Orthologous to human INA (internexin neuronal intermediate filament protein alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ina |
| Official Name | internexin neuronal intermediate filament protein, alpha [Source:MGI Symbol;Acc:MGI:96568] |
| Ensembl ID | ENSMUSG00000034336 |
| Bio databases IDs | |
| Aliases | internexin neuronal intermediate filament protein, alpha |
| Synonyms | alpha internexin, Alpha-Inx, Inexa, internexin neuronal intermediate filament protein alpha, internexin neuronal intermediate filament protein, alpha, internexin neuronal intermediate filament protein α, internexin neuronal intermediate filament protein, α, Intlaa, NEF5, NEUROFILAMENT-66, NF-66, TXBP-1, α Internexin, α-Inx |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ina often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Intermediate filament head (DNA binding) region
- binding protein
- structural constituent of cytoskeleton
- protein binding
- Intermediate filament protein
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- sporadic amyotrophic lateral sclerosis
- uterine serous papillary cancer
regulates
- Tax
- INA
role in cell
- formation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- intermediate filament cytoskeleton
- cytoplasmic ribonucleoprotein granule
- cytoskeleton
- organelle
- postsynaptic region
- cellular membrane
- filamentous network
- neurofilaments
- growth cone
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ina gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neurofilament cytoskeleton organization
- cell differentiation
- intermediate filament organization
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- intermediate filament
- neurofilament
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of cytoskeleton