Wdr1 Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Involved in several processes, including cytoskeleton organization; establishment of planar polarity of follicular epithelium; and platelet formation. Acts upstream of or within positive regulation of actin filament depolymerization; regulation of ventricular cardiac muscle cell membrane repolarization; and sarcomere organization. Located in myelin sheath. Is active in glutamatergic synapse. Is expressed in several structures, including early conceptus; embryo mesenchyme; genitourinary system; heart; and telencephalon. Orthologous to human WDR1 (WD repeat domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wdr1 |
| Official Name | WD repeat domain 1 [Source:MGI Symbol;Acc:MGI:1337100] |
| Ensembl ID | ENSMUSG00000005103 |
| Bio databases IDs | |
| Aliases | WD repeat domain 1 |
| Synonyms | AIP1, D5Wsu185e, HEL-S-52, NORI-1, PFITS, PNAS-29, rede, WD repeat domain 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wdr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- actin filament binding
- WD40 repeats
- actin binding
- WD domain, G-beta repeat
- WD40
- ETGE motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- non-insulin-dependent diabetes mellitus
- periodic fever, immunodeficiency, and thrombocytopenia syndrome
- autoinflammatory disorder
- intellectual developmental disorder 61
- essential thrombocythemia
- idiopathic scoliosis
- breast carcinoma
- neuroticism
- atrial fibrillation
role in cell
- phosphorylation in
- formation
- cell viability
- production in
- quantity
- activation in
- organization
- migration by
- differentiation
- cytokinesis failure in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- myelin enriched fraction
- glutaminergic synapse
- cell junction
- actin cytoskeleton
- Plasma Membrane
- intercellular junctions
- cytosol
- synapse
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wdr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- locomotion
- actin filament depolymerization
- sarcomere organization
- regulation of oligodendrocyte differentiation
- regulation of ventricular cardiomyocyte membrane repolarization
- establishment of planar polarity of follicular epithelium
- sensory perception of sound
- cortical cytoskeleton organization
- neutrophil mediated immunity
- regulation of actin filament depolymerization
- maintenance of epithelial cell apical/basal polarity
- positive regulation of actin filament depolymerization
- apical junction assembly
- platelet formation
- actin filament fragmentation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cell-cell junction
- cytosol
- cell junction
- extracellular region
- cell projection
- cortical actin cytoskeleton
- plasma membrane
- podosome
Molecular Function
What the gene product does at the molecular level
- actin filament binding