Aldh2 Gene Summary [Mouse]
Predicted to enable several functions, including NADH binding activity; carboxylesterase activity; and phenylacetaldehyde dehydrogenase (NAD+) activity. Involved in regulation of dopamine biosynthetic process and regulation of serotonin biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh2 |
| Official Name | aldehyde dehydrogenase 2, mitochondrial [Source:MGI Symbol;Acc:MGI:99600] |
| Ensembl ID | ENSMUSG00000029455 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 2, mitochondrial |
| Synonyms | Ahd-5, AHD-M1, Aldehyde dehydr 2,A2, aldehyde dehydrogenase 2 family member, aldehyde dehydrogenase 2, mitochondrial, ALDH-E2, ALDHI, ALDM, Hepatic aldehyde dehydrogenase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aldh2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- carboxylic ester hydrolase
- electron carrier
- enzyme
- protein binding
- identical protein binding
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
- NAD or NADH binding
- betaine-aldehyde dehydrogenase
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 1
- binding protein
- aldehyde dehydrogenase (NAD)
- phenylacetaldehyde dehydrogenase
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative
- methylmalonic acid semialdehyde dehydrogenase
Pathways
Biological processes and signaling networks where the Aldh2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hypertension
- cirrhosis
- diabetes mellitus
- diastolic dysfunction
- atrial fibrillation
- obesity
- stroke
- Alzheimer disease
- COVID-19
role in cell
- phosphorylation in
- expression in
- apoptosis
- accumulation in
- production in
- number
- quantity
- oxidation
- binding in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- mitochondrial fraction
- cellular membrane
- Nucleus
- Mitochondria
- lipid droplets
- cytosol
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aldh2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aldehyde catabolic process
- carbohydrate metabolic process
- ethanol catabolic process
- alcohol metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
- phenylacetaldehyde dehydrogenase activity
- NAD binding
- electron carrier activity
- aldehyde dehydrogenase [NAD(P)+] activity
- nitroglycerin reductase activity