Mapk8ip3 Gene Summary [Mouse]
Enables MAP-kinase scaffold activity; kinesin binding activity; and protein kinase binding activity. Involved in several processes, including anterograde axonal protein transport; positive regulation of neuron migration; and regulation of MAPK cascade. Acts upstream of or within several processes, including JNK cascade; lung development; and nervous system development. Located in several cellular components, including Golgi membrane; axolemma; and smooth endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; pancreas; retina; and spleen. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mapk8ip3 |
| Official Name | mitogen-activated protein kinase 8 interacting protein 3 [Source:MGI Symbol;Acc:MGI:1353598] |
| Ensembl ID | ENSMUSG00000024163 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 8 interacting protein 3 |
| Synonyms | D17Wsu15e, JIP-3, JSAP1, JSAP1a, JSAP1b, JSAP1c, JSAP1d, Mitogen-activated protein kinase 8 interacting protein 3, mKIAA1066, NEDBA, syd, SYD2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapk8ip3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Procyclic acidic repetitive protein (PARP)
- polo kinase kinase
- TPR/MLP1/MLP2-like protein
- JNK-interacting protein leucine zipper II
- protein kinase binding
- Ezrin/radixin/moesin, alpha-helical domain
- Uso1 / p115 like vesicle tethering protein, C terminal region
- F-type ATP synthase, membrane subunit b
- coiled-coil domain
- JUN kinase binding
- protein binding
- phosphotyrosine binding domain
- Jnk-binding domain
- kinesin binding
- MAP-kinase scaffold protein
- Cell division protein ZapB
- JNK_SAPK-associated protein-1
- Jnk phosphorylation site
Pathways
Biological processes and signaling networks where the Mapk8ip3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with variable brain abnormalities
- neurodevelopmental disorder with or without variable brain abnormalities
- hyperplasia
- cyanosis
- hereditary disorder
- atelectasis
- respiratory failure
- non-insulin-dependent diabetes mellitus
- coronary artery disease
- breast adenocarcinoma
role in cell
- accumulation in
- activation in
- apoptosis
- migration
- accumulation
- formation
- regeneration
- differentiation
- guidance
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cytosol
- Golgi membrane
- axonal membrane
- growth cone
- smooth endoplasmatic reticulum
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapk8ip3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- vesicle-mediated transport
- positive regulation of JNK cascade
- negative regulation of apoptotic process
- protein stabilization
- axon regeneration
- regulation of JNK cascade
Cellular Component
Where in the cell the gene product is active
- growth cone
- dendrite
- perinuclear region of cytoplasm
- cytoplasm
- cell body
- cytoplasmic vesicle
- Golgi membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- kinesin binding
- JUN kinase binding
- MAP-kinase scaffold activity
- receptor signaling complex scaffold activity