Shh Gene Summary [Mouse]
Enables several functions, including cholesterol-protein transferase activity; laminin-1 binding activity; and patched binding activity. Involved in several processes, including hemopoiesis; positive regulation of T cell activation; and regulation of smooth muscle cell differentiation. Acts upstream of or within several processes, including nervous system development; respiratory system development; and tube morphogenesis. Located in several cellular components, including cell surface; extracellular space; and membrane raft. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study brachydactyly type A1; holoprosencephaly 3; and nevoid basal cell carcinoma syndrome. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly (multiple). Orthologous to human SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shh |
| Official Name | sonic hedgehog [Source:MGI Symbol;Acc:MGI:98297] |
| Ensembl ID | ENSMUSG00000002633 |
| Bio databases IDs | |
| Aliases | sonic hedgehog |
| Synonyms | 9530036O11Rik, Dsh, HHG-1, HLP3, HPE3, HX, Hxl3, LOC105375595, M100081, MCOPCB5, ShhNC, SMMCI, sonic hedgehog, sonic hedgehog signaling molecule, TPT, TPTPS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hint (Hedgehog/Intein) domain C-terminal region
- morphogen
- Hint module
- peptidase
- calcium ion binding
- enzyme
- protein binding
- zinc binding domain
- glycosaminoglycan binding
- Hedgehog amino-terminal signalling domain
- Hint (Hedgehog/Intein) domain N-terminal region
- endopeptidase
- laminin binding
- transferase
- zinc ion binding
- Hint
- Cardin-Weintraub motif
- signaling domain
- patched binding
Pathways
Biological processes and signaling networks where the Shh gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic obstructive pulmonary disease
- obesity
- non-small cell lung cancer
- endometrial hyperplasia
- alopecia
- cancer
- kidney injury
- epithelial neoplasia
- epithelial cancer
role in cell
- activation in
- phosphorylation in
- proliferation
- cell death
- expression in
- migration
- apoptosis
- production in
- formation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell surface
- postsynaptic region
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytoplasmic aggregates
- cytosol
- endoplasmic reticulum lumen
- nucleoplasm
- synaptic vesicles
- synapse
- extracellular matrix
- membrane rafts
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung-associated mesenchyme development
- negative regulation of mesenchymal cell apoptotic process
- somite development
- epithelial cell proliferation involved in prostate gland development
- axon guidance
- positive regulation of epithelial cell proliferation involved in prostate gland development
- branching morphogenesis of a tube
- thalamus development
- prostate epithelial cord elongation
- dorsal/ventral pattern formation
- polarity specification of anterior/posterior axis
- neuroblast proliferation
- positive regulation of skeletal muscle tissue development
- positive regulation of transcription, DNA-dependent
- positive regulation of skeletal muscle cell proliferation
- heart looping
- skeletal muscle cell proliferation
- cell fate specification
- positive regulation of kidney smooth muscle cell differentiation
- negative regulation of kidney smooth muscle cell differentiation
- positive regulation of protein import into nucleus
- cell-cell signaling
- positive regulation of cerebellar granule cell precursor proliferation
- pattern specification process
- primary prostatic bud elongation
- organ formation
- positive regulation of immature T cell proliferation in thymus
- ventral midline development
- central nervous system development
- male genitalia development
- mesenchymal cell proliferation involved in lung development
- protein import into nucleus
- hair follicle morphogenesis
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of T cell differentiation in thymus
- regulation of mesenchymal cell proliferation involved in prostate gland development
- negative regulation of alpha-beta T cell differentiation
- salivary gland cavitation
- mesenchymal smoothened signaling pathway involved in prostate gland development
- positive regulation of T cell differentiation in thymus
- Bergmann glial cell differentiation
- positive regulation of cell proliferation
- palate development
- regulation of stem cell proliferation
- apoptotic signaling pathway
- cerebellar granule cell precursor proliferation
- lung epithelium development
- alpha-beta T cell differentiation
- blood coagulation
- positive regulation of transcription from RNA polymerase II promoter
- CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
- epithelial cell proliferation involved in salivary gland morphogenesis
- positive regulation of alpha-beta T cell differentiation
- thymus development
- heart development
- positive regulation of cell division
- neuron fate commitment
- stem cell proliferation
- camera-type eye development
- positive regulation of sclerotome development
- oligodendrocyte differentiation
- T cell differentiation in thymus
- regulation of glial cell proliferation
- spinal cord motor neuron differentiation
- establishment of epithelial cell polarity
- osteoblast development
- embryonic skeletal system development
- androgen metabolic process
- thyroid gland development
- metanephros development
- positive regulation of striated muscle cell differentiation
- dopaminergic neuron differentiation
- branching involved in ureteric bud morphogenesis
- epithelial-mesenchymal cell signaling
- inner ear development
- regulation of prostatic bud formation
- myoblast differentiation
- embryonic digestive tract morphogenesis
- spinal cord dorsal/ventral patterning
- positive regulation of astrocyte differentiation
- artery development
- lymphoid progenitor cell differentiation
- negative regulation of cholesterol efflux
- branching involved in salivary gland morphogenesis
- embryonic digit morphogenesis
- bud outgrowth involved in lung branching
- positive regulation of oligodendrocyte differentiation
- midbrain development
- forebrain development
- hindbrain development
- embryonic forelimb morphogenesis
- embryonic hindlimb morphogenesis
- dorsal/ventral neural tube patterning
- embryonic pattern specification
- determination of left/right asymmetry in lateral mesoderm
- positive regulation of neuroblast proliferation
- smoothened signaling pathway
- trachea morphogenesis
- positive thymic T cell selection
- endocytosis
- cellular response to lithium ion
- negative regulation of gene expression
- positive regulation of mesenchymal cell proliferation involved in ureter development
- neural crest cell migration
- metanephric mesenchymal cell proliferation involved in metanephros development
- positive regulation of gene expression
- striated muscle tissue development
- regulation of gene expression
- positive regulation of Wnt receptor signaling pathway
- prostate gland development
- negative thymic T cell selection
- regulation of protein localization to nucleus
- negative regulation of cell migration
- lung lobe morphogenesis
- oligodendrocyte development
- telencephalon regionalization
- positive regulation of ureter smooth muscle cell differentiation
- negative regulation of ureter smooth muscle cell differentiation
- odontogenesis of dentin-containing tooth
- ectoderm development
- vasculogenesis
- embryonic foregut morphogenesis
- formation of anatomical boundary
- intermediate filament organization
- mesenchymal cell apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- embryonic limb morphogenesis
- self proteolysis
- negative regulation of cell differentiation
- patterning of blood vessels
- regulation of odontogenesis
- metanephric collecting duct development
- canonical Wnt receptor signaling pathway
- pancreas development
- lung development
- negative regulation of transcription elongation from RNA polymerase II promoter
- intein-mediated protein splicing
- limb bud formation
- regulation of proteolysis
- left lung development
- smooth muscle tissue development
- stem cell development
- cell development
- hindgut morphogenesis
- regulation of cell proliferation
- right lung development
- negative regulation of canonical Wnt receptor signaling pathway
- negative regulation of T cell proliferation
- negative regulation of apoptotic process
- T cell proliferation
- positive regulation of smoothened signaling pathway
- protein autoprocessing
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- extracellular space
- membrane raft
- cytosol
- Golgi membrane
- endoplasmic reticulum
- Golgi apparatus
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- glycosaminoglycan binding
- calcium ion binding
- endopeptidase activity
- peptidase activity
- laminin-1 binding
- patched binding
- morphogen activity