Trpv1

Enables calcium channel activity; identical protein binding activity; and temperature-gated ion channel activity. Involved in detection of temperature stimulus involved in sensory perception of pain; monoatomic ion transmembrane transport; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including diet induced thermogenesis; fever generation; and sensory perception of chemical stimulus. Located in neuron projection and plasma membrane. Is active in GABA-ergic synapse and postsynaptic membrane. Is expressed in central nervous system; cochlea; dorsal root ganglion; and eye. Human ortholog(s) of this gene implicated in migraine. Orthologous to human TRPV1 (transient receptor potential cation channel subfamily V member 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trpv1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Trpv1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Trpv1 gene, providing context for its role in the cell.