Trpv1 Gene Summary [Rat]
Enables several functions, including ATP binding activity; calmodulin binding activity; and ligand-gated monoatomic ion channel activity. Involved in several processes, including calcium ion import across plasma membrane; cellular response to temperature stimulus; and negative regulation of establishment of blood-brain barrier. Acts upstream of or within response to heat and response to pH. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is active in postsynaptic membrane. Used to study myocardial infarction and reflex epilepsy. Human ortholog(s) of this gene implicated in migraine. Orthologous to human TRPV1 (transient receptor potential cation channel subfamily V member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trpv1 |
| Official Name | transient receptor potential cation channel, subfamily V, member 1 [Source:RGD Symbol;Acc:628841] |
| Ensembl ID | ENSRNOG00000019486 |
| Bio databases IDs | |
| Aliases | transient receptor potential cation channel, subfamily V, member 1 |
| Synonyms | capsaicin receptor, OTRPC1, transient receptor potential cation channel subfamily V member 1, transient receptor potential cation channel, subfamily V, member 1, TRPV1 SON, vanilloid (capsaicin) receptor, VR-1, Vr1l1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trpv1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- Ankyrin repeats (many copies)
- walker type B motif
- ATP binding
- phosphoprotein binding
- identical protein binding
- ion channel
- Ankyrin repeat
- intracellular domain
- transient-receptor-potential calcium channel protein
- transmembrane receptor
- Transient Receptor Potential channel, Vanilloid subfamily (TRPV)
- ankyrin repeats
- vanilloid binding domain
- extracellular domain
- phosphatidylinositol 4,5-biphosphate binding domain
- Ion transport protein
- calmodulin binding
- channel/pore class transporter
- calcium channel
- walker type A motif
- Ankyrin repeats (3 copies)
- chloride channel regulator
- extracellular ligand-gated ion channel
- protein binding
- cation transporter
- calcium-release channel
- phosphatidylinositol binding
- phosphorylation site
- tetrameric assembly domain
- voltage-gated calcium channel
- transmembrane domain
- ligand-gated ion channel
- cation channel
Pathways
Biological processes and signaling networks where the Trpv1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- herpes zoster
- postherpetic neuralgia
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- pain
- cancer
- postoperative pain
- neoplasia
- COVID-19
role in cell
- calcium response in
- migration
- expression in
- function
- cell death
- proliferation
- apoptosis
- damage
- growth
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular compartment
- longitudinal sarcoplasmic reticulum fraction
- intracellular structures
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- cellular membrane
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- cytosol
- plasma membrane extracellular face
- postsynaptic membrane
- nucleoli
- synaptic vesicles
- neurites
- nerve ending
- axon initial segments
- synapse
- sarcoplasmic reticulum membrane
- cellular protrusions
- perikaryon
- axons
- dendrites
- presynaptic terminals
- excitatory synapses
- C fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trpv1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate secretion
- positive regulation of nitric oxide biosynthetic process
- negative regulation of establishment of blood-brain barrier
- chemosensory behavior
- diet induced thermogenesis
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of mitochondrial membrane potential
- protein homotetramerization
- cellular response to heat
- behavioral response to pain
- calcium ion transmembrane transport
- cellular response to alkaloid
- thermoception
- negative regulation of heart rate
- cellular response to tumor necrosis factor
- cellular response to ATP
- calcium-mediated signaling
- sensory perception of mechanical stimulus
- regulation of excitatory postsynaptic membrane potential
- negative regulation of systemic arterial blood pressure
- peptide secretion
- cell surface receptor signaling pathway
- fever generation
- response to peptide hormone stimulus
- elevation of cytosolic calcium ion concentration
- detection of temperature stimulus involved in thermoception
- microglial cell activation
- lipid metabolic process
- positive regulation of apoptotic process
- detection of chemical stimulus involved in sensory perception of pain
- cellular response to acidity
- cellular response to temperature stimulus
- smooth muscle contraction involved in micturition
- detection of temperature stimulus involved in sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- dendritic spine membrane
- membrane
- external side of plasma membrane
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- calcium-release channel activity
- calcium channel activity
- phosphatidylinositol binding
- excitatory extracellular ligand-gated ion channel activity
- extracellular ligand-gated ion channel activity
- voltage-gated calcium channel activity
- ATP binding
- chloride channel regulator activity
- calmodulin binding
- transmembrane signaling receptor activity
- protein binding
- metal ion binding
- phosphoprotein binding