Rcn1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Acts upstream of or within camera-type eye development and in utero embryonic development. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including brain; genitourinary system; semicircular canal; spinal cord ventricular layer; and vertebral axis musculature. Orthologous to human RCN1 (reticulocalbin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rcn1 |
| Official Name | reticulocalbin 1 [Source:MGI Symbol;Acc:MGI:104559] |
| Ensembl ID | ENSMUSG00000005973 |
| Bio databases IDs | |
| Aliases | reticulocalbin 1 |
| Synonyms | HEL-S-84, PIG20, RCAL, RCN, Reticulocalbin 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rcn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain pair
- calcium ion binding
- EFh
- EF-hand, calcium binding motif, found in CREC-EF hand family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- rectal adenocarcinoma
- colon adenocarcinoma
- epithelial cancer
- colorectal carcinomagenesis
- rectum cancer
- colon epithelial cancer
- rectosigmoid adenocarcinoma
- colorectal cancer distal to the spelic flexure
- cecum adenocarcinoma
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rcn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- in utero embryonic development
- camera-type eye development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding