Eps8l1 Gene Summary [Mouse]
Predicted to enable T cell receptor binding activity and actin filament binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to act upstream of or within Rac protein signal transduction. Predicted to be located in cytosol and ruffle. Predicted to be part of protein-containing complex. Predicted to be active in ruffle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and respiratory system. Orthologous to human EPS8L1 (EPS8 signaling adaptor L1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Eps8l1 |
| Official Name | EPS8-like 1 [Source:MGI Symbol;Acc:MGI:1914675] |
| Ensembl ID | ENSMUSG00000006154 |
| Bio databases IDs | |
| Aliases | EPS8-like 1 |
| Synonyms | 2310051G19Rik, 4632407K17Rik, AW060268, DRC3, EPS8-like 1, EPS8R1, EPS8 signaling adaptor L1, PP10566 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eps8l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin filament binding
- SAM (Sterile alpha motif )
- actin binding
- guanyl-nucleotide exchange factor
- SAM domain (Sterile alpha motif)
- T-cell receptor binding
- protein binding
- Pleckstrin homology-like domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- cytosol
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eps8l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Rho protein signal transduction
- Rho protein signal transduction
- positive regulation of ruffle assembly
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
- ruffle membrane
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- cadherin binding
- T cell receptor binding
- guanyl-nucleotide exchange factor activity