Abi1 Gene Summary [Mouse]
Enables protein tyrosine kinase activator activity and signaling adaptor activity. Acts upstream of or within megakaryocyte development; plasma membrane bounded cell projection morphogenesis; and somitogenesis. Located in lamellipodium and neuron projection. Part of SCAR complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human ABI1 (abl interactor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abi1 |
| Official Name | abl interactor 1 [Source:MGI Symbol;Acc:MGI:104913] |
| Ensembl ID | ENSMUSG00000058835 |
| Bio databases IDs | |
| Aliases | abl interactor 1 |
| Synonyms | Abelson interactor 1, Abl binding protein 4, ABLBP4, abl-interactor 1, E3B1, Eps8 binding, NAP1, Nap1 binding, NAP1BP, SSH3BP, SSH3BP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Abl-interactor HHR
- cytoskeletal protein binding
- protein binding activity, bridging
- coiled-coil domain
- Eps8 protein binding region
- protein binding
- proline rich domain
- SH3-domain binding
- protein tyrosine kinase activator
- Sh3 domain binding motif
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Abi1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- neonatal late-onset sepsis
- neoplastic cell transformation
- edema
- growth failure
- bleeding
- major depression
- exencephaly
- chorioallantoic membrane fusion failure
- primary myelofibrosis
role in cell
- formation
- activation in
- growth
- proliferation
- phosphorylation in
- differentiation
- binding in
- migration
- conversion
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytoskeleton
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- vesicles
- Endoplasmic Reticulum
- actin filaments
- cytosol
- neurites
- synapse
- anchoring junction
- filopodia
- cell membrane leading edge
- postsynaptic density
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- somitogenesis
- actin polymerization or depolymerization
- positive regulation of protein tyrosine kinase activity
- negative regulation of cell proliferation
- lamellipodium morphogenesis
- megakaryocyte development
- transmembrane receptor protein tyrosine kinase signaling pathway
- dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- growth cone
- postsynaptic density
- nucleus
- SCAR complex
- extracellular vesicular exosome
- cytoskeleton
- filopodium tip
- cytosol
- endoplasmic reticulum
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling adaptor activity
- cadherin binding
- protein tyrosine kinase activator activity
- SH3 domain binding
- cytoskeletal protein binding