Ttc5 Gene Summary [Mouse]
Enables DNA binding activity and chromatin binding activity. Involved in DNA damage response and cellular response to starvation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in several cellular components, including cytoplasmic vesicle; cytosol; and mitochondrion. Orthologous to human TTC5 (tetratricopeptide repeat domain 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ttc5 |
| Official Name | tetratricopeptide repeat domain 5 [Source:MGI Symbol;Acc:MGI:2683584] |
| Ensembl ID | ENSMUSG00000006288 |
| Bio databases IDs | |
| Aliases | tetratricopeptide repeat domain 5 |
| Synonyms | 5930437N14, AW743060, NEDCAFD, STRAP, tetratricopeptide repeat domain 5, Ttc5 TSS126477, Ttc5 TSS126480 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ttc5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tetratricopeptide repeat protein 5 OB fold domain
- ribosome binding
- chromatin binding
- protein binding
- p53-binding domain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- neurodevelopmental disorder with cerebral atrophy and variable facial dysmorphism
- epithelial uterine cancer
- osteoarthritis
- prostate cancer
- early-onset high myopia
- cervical carcinoma
role in cell
- apoptosis
- DNA damage response
- contact growth inhibition
- response
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ttc5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- positive regulation of mRNA catabolic process
- cellular response to starvation
- positive regulation of transcription from RNA polymerase II promoter
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- cytosol
- cytoplasmic vesicle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- ribosome binding
- chromatin binding