Gnpat Gene Summary [Mouse]
Enables glycerone-phosphate O-acyltransferase activity. Acts upstream of or within several processes, including cell junction assembly; cerebellum morphogenesis; and ether lipid biosynthetic process. Located in peroxisome. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study disease of mental health and rhizomelic chondrodysplasia punctata type 2. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata type 2. Orthologous to human GNPAT (glyceronephosphate O-acyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gnpat |
| Official Name | glyceronephosphate O-acyltransferase [Source:MGI Symbol;Acc:MGI:1343460] |
| Ensembl ID | ENSMUSG00000031985 |
| Bio databases IDs | |
| Aliases | glyceronephosphate O-acyltransferase |
| Synonyms | Acyl CoA Dihydroxyacetone Phosphate Acyltransferase, D1Ertd819e, DAP-AT, DHAPAT, glyceronephosphate O-acyltransferase, RCDP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gnpat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- glycerone-phosphate O-acyltransferase
- enzyme
- protein binding
- Acyltransferase
- Glycerol-3-phosphate acyltransferase C-terminal region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rhizomelic chondrodysplasia punctata type 2
- hypoplasia
- Alzheimer disease
- lenticonus
- cataract disease
- rhizomelic chondrodysplasia punctata
- hyperactive behavior
- androgenic alopecia
- microphthalmia
- disproportionate dwarfism
phenotypes
- abnormal Purkinje cell morphology
- abnormal cerebellar foliation
- abnormal cerebellar granule cell migration
- abnormal cerebral hemisphere morphology
- abnormal eye anterior chamber morphology
- abnormal lipid homeostasis
- abnormal myelination
- abnormal paranodal axoglial junction morphology
- abnormal paranode morphology
- abnormal retinal pigment epithelium morphology
- abnormal seminiferous tubule morphology
- abnormal social investigation
- arrest of male meiosis
- azoospermia
- cataract
- decreased anxiety-related response
- decreased body weight
- decreased brain weight
- decreased freezing behavior
- decreased nerve conduction velocity
- decreased stereotypic behavior
- disproportionate dwarf
- enhanced contextual conditioning behavior
- enhanced cued conditioning behavior
- hyperactivity
- increased coping response
- lenticonus
- male infertility
- microphthalmia
- optic nerve hypoplasia
- persistence of hyaloid vascular system
- postnatal growth retardation
- premature death
- short limbs
- small cerebellum
- small ovary
role in cell
- proliferation
- activation
- migration
- assembly
- growth
- organization
- abnormal morphology
- ferroptosis
- lipotoxicity in
- myelination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- peroxisomal matrix
- intracellular membrane-bounded organelle
- cytosol
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gnpat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- phospholipid biosynthetic process
- response to starvation
- response to nutrient
- response to xenobiotic stimulus
- fatty acid metabolic process
- phosphatidic acid biosynthetic process
- ether lipid biosynthetic process
- cerebellum morphogenesis
- synapse assembly
- paranodal junction assembly
- triglyceride biosynthetic process
- response to fatty acid
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- peroxisome
- mitochondrial membrane
- membrane
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- glycerone-phosphate O-acyltransferase activity
- glycerol-3-phosphate O-acyltransferase activity