Tll1 Gene Summary [Mouse]
Enables collagen binding activity. Predicted to be involved in dorsal/ventral pattern formation and protein processing. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; cardiovascular system; hepatic primordium; sclerotome condensation; and trachea mesenchyme. Human ortholog(s) of this gene implicated in atrial heart septal defect 6; congenital heart disease; and coronary artery disease. Orthologous to human TLL1 (tolloid like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tll1 |
| Official Name | tolloid-like [Source:MGI Symbol;Acc:MGI:106923] |
| Ensembl ID | ENSMUSG00000053626 |
| Bio databases IDs | |
| Aliases | tolloid-like |
| Synonyms | ASD6, b2b2476Clo, TLL, tolloid-like, tolloid-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tll1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- Astacin (Peptidase family M12A)
- Zinc-dependent metalloprotease
- EGF-like domain
- EGF_CA
- ZnMc
- protease domain
- serine endopeptidase
- CUB
- collagen binding
- EGF domain
- Coagulation Factor Xa inhibitory site
- metalloendopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- dementia
- edema
- congestive heart failure
- atrial septal defect type 6
- post-traumatic stress disorder
- bleeding
- congenital heart disease
- hepatocellular carcinoma
- liver cancer
role in cell
- production in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tll1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- cell differentiation
- protein processing
- collagen fibril organization
- dorsal/ventral pattern formation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- calcium ion binding
- serine-type endopeptidase activity
- metalloendopeptidase activity