Twsg1 Gene Summary [Mouse]
Enables heparin binding activity. Acts upstream of or within several processes, including BMP signaling pathway; negative regulation of osteoblast differentiation; and regulation of BMP signaling pathway. Located in extracellular space. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; sensory organ; and skeleton. Orthologous to human TWSG1 (twisted gastrulation BMP signaling modulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Twsg1 |
| Official Name | twisted gastrulation BMP signaling modulator 1 [Source:MGI Symbol;Acc:MGI:2137520] |
| Ensembl ID | ENSMUSG00000024098 |
| Bio databases IDs | |
| Aliases | twisted gastrulation BMP signaling modulator 1 |
| Synonyms | 1810013J15RIK, 9030422N06Rik, D17Ertd403e, LOC100910454, TSG, Twg, twisted gastrulation BMP signaling modulator 1, TWSG1 isoform 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Twsg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Twisted gastrulation (Tsg) protein conserved region
- protein binding
- TGFbeta binding
- heparin binding
Pathways
Biological processes and signaling networks where the Twsg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- esophageal squamous cell carcinoma
- subarachnoid hemorrhage
- thrombocytopenia
- esophageal squamous cell cancer
- pulmonary fibrosis
- gait disturbance
- dwarfism
- lymphopenia
- growth failure
role in cell
- proliferation
- apoptosis
- number
- expression in
- differentiation
- activation
- response
- ossification by
- abnormality
- hematopoiesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Twsg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hemopoiesis
- chondrocyte differentiation
- negative regulation of osteoblast differentiation
- salivary gland morphogenesis
- negative regulation of BMP signaling pathway
- positive regulation of BMP signaling pathway
- forebrain development
- negative regulation of CD4-positive, alpha-beta T cell activation
- ossification
- BMP signaling pathway
- camera-type eye development
- positive regulation of SMAD protein import into nucleus
- mesoderm formation
- regulation of BMP signaling pathway
- negative regulation of cytokine production
- negative regulation of CD4-positive, alpha-beta T cell proliferation
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- transforming growth factor beta binding
- protein binding
- heparin binding