Chtop Gene Summary [Mouse]
Predicted to enable methyl-CpG binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in nucleolus. Predicted to be part of transcription export complex. Predicted to be active in nuclear speck. Is expressed in several structures, including alimentary system; dorsal root ganglion; integumental system; olfactory epithelium; and thymus. Orthologous to human CHTOP (chromatin target of PRMT1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chtop |
| Official Name | chromatin target of PRMT1 [Source:MGI Symbol;Acc:MGI:1913761] |
| Ensembl ID | ENSMUSG00000001017 |
| Bio databases IDs | |
| Aliases | chromatin target of PRMT1 |
| Synonyms | 2500003M10Rik, C10orf77, C1orf77, chromatin target of PRMT1, DKFZP547E1010, FL-SRAG, FOP, pp7704, SRAG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chtop often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyl-CpG binding
- protein binding
- glycine arginine rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- gastric epithelial cancer
- neuroinflammation
phenotypes
- abnormal joint morphology
- decreased circulating calcium level
- preweaning lethality complete penetrance
- abnormal Wolffian duct morphology
- abnormal abdominal muscle morphology
- abnormal adenohypophysis morphology
- abnormal atrioventricular valve morphology
- abnormal azygos vein topology
- abnormal brachial plexus formation
- abnormal carotid artery origin
- abnormal cervical atlas morphology
- abnormal choroid plexus morphology
- abnormal dorsal pancreas topology
- abnormal ductus venosus morphology
- abnormal ductus venosus valve topology
- abnormal eye morphology
- abnormal eye muscle morphology
- abnormal fetal atrioventricular canal morphology
- abnormal forebrain morphology
- abnormal hepatic portal vein formation
- abnormal hepatic portal vein morphology
- abnormal hyoid bone body morphology
- abnormal interventricular foramen morphology
- abnormal maxilla morphology
- abnormal neurohypophysis morphology
- abnormal olfactory bulb position
- abnormal optic cup morphology
- abnormal optic stalk morphology
- abnormal pancreas topology
- abnormal pineal gland morphology
- abnormal placenta morphology
- abnormal placental labyrinth vasculature morphology
- abnormal rectum morphology
- abnormal salivary gland morphology
- abnormal small intestine placement
- abnormal spongiotrophoblast layer morphology
- abnormal subclavian artery origin
- abnormal thyroid gland morphology
- abnormal ureter topology
- abnormal vertebral artery topology
- abnormal vertebral body morphology
- abnormal viscerocranium morphology
- abnormal vitelline vein connection
- abnormal vitelline vein topology
- absent celiac artery
- absent costovertebral joint
- absent dorsal root ganglion
- absent ductus venosus valve
- absent extracranial vertebral artery segment
- absent hypoglossal canal
- absent hypoglossal nerve
- absent intrahepatic inferior vena cava segment
- absent olfactory bulb
- absent parasellar internal carotid artery
- absent spleen
- absent vertebrae
- absent vertebral arch
- anal atresia
- anastomosis between common carotid and vertebral artery
- anomalous pulmonary venous connection
- arteriovenous malformation
- bicuspid aortic valve
- blind ureter
- common atrium
- decreased cervical vertebrae number
- decreased rib number
- decreased thoracic vertebrae number
- diaphragmatic hernia
- double outlet right ventricle
- ductus venosus stenosis
- embryo cyst
- fetal growth retardation
- fused dorsal root ganglion
- fused right lung lobes
- fusion of atlas and occipital bones
- fusion of vertebral arches
- heterochrony
- holoprosencephaly
- internal hemorrhage
- intestinal stenosis
- lethality throughout fetal growth and development incomplete penetrance
- muscular ventricular septal defect
- myelocele
- ostium primum atrial septal defect
- pelvic kidney
- perimembraneous ventricular septal defect
- persistent truncus arteriosis
- reduced sympathetic cervical ganglion size
- retro-esophageal left subclavian artery
- retroesophageal right subclavian artery
- rib bifurcation
- rib fusion
- right aortic arch
- scoliosis
- small nodose ganglion
- small superior cervical ganglion
- spleen hypoplasia
- subcutaneous edema
- thin hypoglossal nerve
- thyroid gland hypoplasia
- urinary bladder hypoplasia
role in cell
- quantity
- expression in
- binding in
- cell death
- morphology
- metabolism in
- remodeling
- proteolysis in
- biosynthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chtop gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- chromatin remodeling
- positive regulation of ATPase activity
- positive regulation of helicase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- nucleolus
- transcription export complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- methyl-CpG binding