Chtop Gene Summary [Mouse]
Predicted to enable methyl-CpG binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in nucleolus. Predicted to be part of transcription export complex. Predicted to be active in nuclear speck. Is expressed in several structures, including alimentary system; dorsal root ganglion; integumental system; olfactory epithelium; and thymus. Orthologous to human CHTOP (chromatin target of PRMT1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chtop |
| Official Name | chromatin target of PRMT1 [Source:MGI Symbol;Acc:MGI:1913761] |
| Ensembl ID | ENSMUSG00000001017 |
| Bio databases IDs | |
| Aliases | chromatin target of PRMT1 |
| Synonyms | 2500003M10Rik, C10orf77, C1orf77, chromatin target of PRMT1, DKFZP547E1010, FL-SRAG, FOP, pp7704, SRAG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chtop often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyl-CpG binding
- protein binding
- glycine arginine rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- gastric epithelial cancer
- neuroinflammation
role in cell
- quantity
- expression in
- binding in
- cell death
- morphology
- metabolism in
- remodeling
- proteolysis in
- biosynthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chtop gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- chromatin remodeling
- positive regulation of ATPase activity
- positive regulation of helicase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- nucleolus
- transcription export complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding
- methyl-CpG binding