Scube2 Gene Summary [Mouse]
Enables hedgehog family protein binding activity. Acts upstream of or within several processes, including chondrocyte differentiation involved in endochondral bone morphogenesis; positive regulation of chondrocyte proliferation; and positive regulation of osteoblast differentiation. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; neural ectoderm; sensory organ; and skeleton. Orthologous to human SCUBE2 (signal peptide, CUB domain and EGF like domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scube2 |
| Official Name | signal peptide, CUB domain, EGF-like 2 [Source:MGI Symbol;Acc:MGI:1928765] |
| Ensembl ID | ENSMUSG00000007279 |
| Bio databases IDs | |
| Aliases | signal peptide, CUB domain, EGF-like 2 |
| Synonyms | 4932442O19Rik, CEGB1, CEGF1, CEGP1, RGD1563998, Scube2-ps1, scube/You, signal peptide, CUB domain and EGF like domain containing 2, signal peptide, CUB domain, EGF-like 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scube2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- CUB
- Tyrosine-protein kinase ephrin type A/B receptor-like
- EGF domain
- protein binding
- identical protein binding
- Coagulation Factor Xa inhibitory site
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- epithelial cancer
- prostate cancer
- chronic obstructive pulmonary disease
- Huntington disease
- prostatic carcinoma
- non-small cell lung carcinoma
- non-small cell lung cancer
- insomnia
- breast carcinoma
role in cell
- proliferation
- differentiation
- number
- ossification by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scube2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- lipid binding