Scube1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within positive regulation of smoothened signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in several structures, including allantois; embryo ectoderm; embryo mesenchyme; forelimb bud; and genitourinary system. Orthologous to human SCUBE1 (signal peptide, CUB domain and EGF like domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Scube1 |
| Official Name | signal peptide, CUB domain, EGF-like 1 [Source:MGI Symbol;Acc:MGI:1890616] |
| Ensembl ID | ENSMUSG00000016763 |
| Bio databases IDs | |
| Aliases | signal peptide, CUB domain, EGF-like 1 |
| Synonyms | 7330410C13Rik, A630023E24Rik, FLJ30901, signal peptide, CUB domain and EGF like domain containing 1, signal peptide, CUB domain, EGF-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scube1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- CUB
- Tyrosine-protein kinase ephrin type A/B receptor-like
- calcium ion binding
- EGF domain
- protein binding
- identical protein binding
- transmembrane receptor
- Coagulation Factor Xa inhibitory site
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- peripheral neuropathy
- organismal death
- colorectal cancer
- Parkinson disease
- coronary artery disease
- inflammatory bowel disease
- laser induced choroidal neovascularization
role in cell
- expression in
- invasion by
- cell viability
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scube1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- signal transduction
- positive regulation of smoothened signaling pathway
- post-embryonic development
- endothelial cell differentiation
- blood coagulation
- adult heart development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium ion binding