Twist2 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity; chromatin binding activity; and protein domain specific binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including face morphogenesis; negative regulation of cell differentiation; and negative regulation of macromolecule biosynthetic process. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in Barber-Say syndrome and ablepharon macrostomia syndrome. Orthologous to human TWIST2 (twist family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Twist2 |
| Official Name | twist basic helix-loop-helix transcription factor 2 [Source:MGI Symbol;Acc:MGI:104685] |
| Ensembl ID | ENSMUSG00000007805 |
| Bio databases IDs | |
| Aliases | twist basic helix-loop-helix transcription factor 2 |
| Synonyms | AMS, BBRSAY, bHLHa39, DERMO1, FFDD3, SETLSS, twist basic helix-loop-helix transcription factor 2, twist family bHLH transcription factor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Twist2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- chromatin binding
- transcription factor binding
- protein domain specific binding
- helix-loop-helix domain
- protein binding
- Helix-loop-helix DNA-binding domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Twist2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insulin resistance
- invasive breast cancer
- breast cancer
- epithelial cancer
- obesity
- liver cancer
- breast carcinoma
- Setleis syndrome
- cachexia
role in cell
- expression in
- migration
- differentiation
- apoptosis
- proliferation
- activation in
- cell cycle progression
- quantity
- accumulation in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Twist2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to insulin stimulus
- negative regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- cell differentiation
- response to organic cyclic compound
- developmental process
- negative regulation of osteoblast differentiation
- regulation of transcription from RNA polymerase II promoter
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity