Acot12 Gene Summary [Mouse]
Enables ATP binding activity and acetyl-CoA hydrolase activity. Acts upstream of or within acetyl-CoA metabolic process. Predicted to be located in intercellular bridge and nucleoplasm. Predicted to be active in cytosol. Is expressed in alimentary system and liver. Orthologous to human ACOT12 (acyl-CoA thioesterase 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acot12 |
| Official Name | acyl-CoA thioesterase 12 [Source:MGI Symbol;Acc:MGI:1921406] |
| Ensembl ID | ENSMUSG00000021620 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 12 |
| Synonyms | 1300004O04Rik, 4930449F15Rik, acyl-CoA thioesterase 12, Cach, CACH-1, mCACH-1, rACH, STARD15, THEAL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acot12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SRPBCC domain
- Thioesterase superfamily
- acetyl-CoA hydrolase
- ATP binding
- hot_dog
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- diabetic nephropathy
- osteoarthritis
- surgically induced osteoarthritis
- brain atrophy
- orofacial cleft
regulated by
- MYC
- phosphatidic acid
- high erucic acid rapeseed oil
- insulin
- mir-155
- Hepatitis B virus subtype ayw
- dioleoylphosphatidic acid
- monooleylphosphatidic acid
- dimyristoylphosphatidylglycerol
role in cell
- expression in
- apoptosis
- quantity
- migration
- invasion by
- deposition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic bridges
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acot12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- acetyl-CoA metabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- acetyl-CoA hydrolase activity
- identical protein binding
- protein binding
- lipid binding
- carboxylic ester hydrolase activity