Tcap Gene Summary [Mouse]
Predicted to enable several functions, including BMP binding activity; cytoskeletal protein binding activity; and titin Z domain binding activity. Predicted to be a structural constituent of muscle. Involved in adult heart development; otic vesicle formation; and somitogenesis. Located in Z disc. Is expressed in several structures, including heart; otocyst; and somite. Used to study autosomal recessive limb-girdle muscular dystrophy type 2G. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2G and hypertrophic cardiomyopathy 25. Orthologous to human TCAP (titin-cap). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcap |
| Official Name | titin-cap [Source:MGI Symbol;Acc:MGI:1330233] |
| Ensembl ID | ENSMUSG00000007877 |
| Bio databases IDs | |
| Aliases | titin-cap |
| Synonyms | CMD1N, CMH25, LGMD2G, LGMDR7, TELE, telethonin, titin-cap |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine binding
- structural constituent of muscle
- cytoskeletal protein binding
- protein binding activity, bridging
- ion channel binding
- protein domain specific binding
- protein binding
- Telethonin protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- familial hypertrophic cardiomyopathy type 25
- limb-girdle muscular dystrophy type 2
- hypertrophic cardiomyopathy
- limb-girdle muscular dystrophy type 2G
- primary biliary cirrhosis
- dilated cardiomyopathy
- primary dilated cardiomyopathy
- familial hypertrophic cardiomyopathy
role in cell
- development
- organization
- assembly
- structural integrity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sarcomere
- cytosol
- I band
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- skeletal muscle thin filament assembly
- sarcomere organization
- cardiac muscle contraction
- cardiac muscle hypertrophy
- sarcomerogenesis
- adult heart development
- detection of mechanical stimulus
- skeletal muscle contraction
- somitogenesis
- otic vesicle formation
- cardiac muscle cell development
- cardiac myofibril assembly
- skeletal muscle myosin thick filament assembly
- response to muscle stretch
- cardiac muscle hypertrophy in response to stress
- detection of muscle stretch
- cardiac muscle tissue morphogenesis
Cellular Component
Where in the cell the gene product is active
- Z disc
- I band
- cytosol
Molecular Function
What the gene product does at the molecular level
- BMP binding
- structural constituent of muscle
- protein binding
- FATZ binding
- titin binding
- protein binding, bridging
- ion channel binding
- titin Z domain binding
- binding, bridging