Myoz1 Gene Summary [Mouse]
Enables protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including negative regulation of calcineurin-NFAT signaling cascade; negative regulation of skeletal muscle tissue regeneration; and sarcomere organization. Acts upstream of or within with a positive effect on skeletal muscle fiber adaptation. Located in actin cytoskeleton. Is expressed in diaphragm; heart; musculature; and tongue. Orthologous to human MYOZ1 (myozenin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myoz1 |
| Official Name | myozenin 1 [Source:MGI Symbol;Acc:MGI:1929471] |
| Ensembl ID | ENSMUSG00000068697 |
| Bio databases IDs | |
| Aliases | myozenin 1 |
| Synonyms | 2310001N11Rik, CS-2, FATZ, MYOZ, myozenin 1, RGD1561064 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myoz1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcineurin-binding protein (Calsarcin)
- cytoskeletal protein binding
- type 1 serine/threonine specific protein phosphatase inhibitor
- actinin binding
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- actin cytoskeleton
- Nucleus
- sarcomere
- I band
- Z line
- pseudopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myoz1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of skeletal muscle tissue regeneration
- myofibril assembly
- negative regulation of transcription from RNA polymerase II promoter
- wound healing
- skeletal muscle tissue development
- negative regulation of calcineurin-NFAT signaling cascade
- sarcomere organization
- skeletal muscle fiber adaptation
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- actin cytoskeleton
- pseudopodium
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase inhibitor activity
- protein binding
- actin binding
- actinin binding
- FATZ binding
- telethonin binding