Brme1 Gene Summary [Mouse]
Enables damaged DNA binding activity. Involved in meiosis I; protein localization to site of double-strand break; and spermatogenesis. Acts upstream of or within double-strand break repair via homologous recombination and reciprocal meiotic recombination. Located in chromosome. Is active in site of double-strand break. Is expressed in several structures, including 4th ventricle choroid plexus; genitourinary system; meninges; nasal epithelium; and thoracic segment skeleton. Orthologous to human BRME1 (break repair meiotic recombinase recruitment factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brme1 |
| Official Name | break repair meiotic recombinase recruitment factor 1 [Source:MGI Symbol;Acc:MGI:1921916] |
| Ensembl ID | ENSMUSG00000008129 |
| Bio databases IDs | |
| Aliases | break repair meiotic recombinase recruitment factor 1 |
| Synonyms | 4930432K21Rik, break repair meiotic recombinase recruitment factor 1, C19orf57, Mamerr, MEIOK21, MRM, RGD1306072 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brme1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- damaged DNA binding
- Break repair meiotic recombinase recruitment factor 1
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hodgkin lymphoma
- Hodgkin disease
- rheumatoid arthritis
- renal clear cell adenocarcinoma
- renal clear cell cancer
- oligodendroglioma
- glioma formation
- monoclonal gammopathy of undertermined significance
- chronic lymphocytic leukemia
- inclusion body myositis
regulates
role in cell
- meiosis I
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brme1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- female meiosis I
Cellular Component
Where in the cell the gene product is active
- chromosome
Molecular Function
What the gene product does at the molecular level
- protein binding