Mga Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human MGA (MAX dimerization protein MGA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mga |
| Official Name | MAX gene associated [Source:MGI Symbol;Acc:MGI:1352483] |
| Ensembl ID | ENSMUSG00000033943 |
| Bio databases IDs | |
| Aliases | MAX gene associated |
| Synonyms | C130042M01Rik, D030062C11RIK, FLJ12634, MAD5, Max dimerization protein 5, MAX dimerization protein MGA, MAX gene associated, MXD5, POF26, RGD1561597 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mga often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- Family of unknown function (DUF5585)
- transcription regulator
- nucleic acid binding
- MGA, conserved domain
- basic Helix Loop Helix (bHLH) domain superfamily
- protein binding
- sequence-specific DNA binding
- zDHHC ankyrin repeat binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- basic helix-loop-helix-leucine zipper domain
- T-box
- double-stranded DNA binding
- DNA-binding domain of the T-box transcription factor family
- helix loop helix domain
- Helix-loop-helix DNA-binding domain
- transcription factor activity
- T-box domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- neuroblastoma
- neuroblastoma formation
- osteosarcoma
- osteosarcomagenesis
- precursor B-cell acute lymphoblastic leukemia
- lung adenocarcinoma
- lung adenocarcinoma formation
- overnutrition
- progression free survival
role in cell
- proliferation
- expression in
- apoptosis
- binding in
- invasion by
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mga gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- cell fate specification
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- MLL1 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity