Oat Gene Summary [Mouse]
Predicted to enable identical protein binding activity; ornithine aminotransferase activity; and pyridoxal phosphate binding activity. Predicted to be involved in arginine catabolic process to glutamate and arginine catabolic process to proline via ornithine. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; integumental system; respiratory system; and sensory organ. Used to study gyrate atrophy. Human ortholog(s) of this gene implicated in gyrate atrophy. Orthologous to human OAT (ornithine aminotransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oat |
| Official Name | ornithine aminotransferase [Source:MGI Symbol;Acc:MGI:97394] |
| Ensembl ID | ENSMUSG00000030934 |
| Bio databases IDs | |
| Aliases | ornithine aminotransferase |
| Synonyms | GACR, HOGA, OATASE, OKT, ornithine aminotransferase, Ornithine-oxo-acid aminotransferase, Ornithine Transaminase, rhg, rOAT |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Oat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenosylmethionine-8-amino-7-oxononanoate transaminase
- acetylornithine transaminase
- 4-aminobutyrate aminotransferase, eukaryotic type
- Aminotransferase class-III
- 4-aminobutyrate aminotransferase, prokaryotic type
- enzyme
- protein binding
- identical protein binding
- ornithine aminotransferase
- ornithine-oxo-acid transaminase
- succinylornithine transaminase family
- transaminase, acetylornithine/succinylornithine family
- AAT_I
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- septic shock
- gyrate atrophy
- retinal dystrophy
- lung adenocarcinoma
- lung adenocarcinoma formation
- idiopathic scoliosis
- orotic aciduria
role in cell
- expression in
- lack
- number
- downregulation in
- abnormal morphology
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial matrix
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Oat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- arginine catabolic process to proline via ornithine
- arginine catabolic process to glutamate
- visual perception
- L-proline biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrial matrix
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- pyridoxal phosphate binding
- protein binding
- ornithine-oxo-acid transaminase activity