Cibar1 Gene Summary [Mouse]
Predicted to enable phospholipid binding activity. Involved in cilium assembly; limb morphogenesis; and positive regulation of smoothened signaling pathway. Located in ciliary basal body; ciliary transition zone; and mitochondrion. Is expressed in apical ectodermal ridge; limb bud; and limb mesenchyme. Used to study polydactyly. Orthologous to human CIBAR1 (CBY1 interacting BAR domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cibar1 |
| Official Name | CBY1 interacting BAR domain containing 1 [Source:MGI Symbol;Acc:MGI:1915349] |
| Ensembl ID | ENSMUSG00000028218 |
| Bio databases IDs | |
| Aliases | CBY1 interacting BAR domain containing 1 |
| Synonyms | 6720467C03Rik, BARMR1, CBY1 interacting BAR domain containing 1, FAM92A, FAM92A1, PAPA9, RGD1310681 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cibar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- Vps5 C terminal like
- protein binding
- Bin/Amphiphysin/Rvs domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ciliary transition zone
- sperm annulus
- cilia
- Nucleus
- basal bodies
- centriole
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cibar1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- cilium morphogenesis
- positive regulation of smoothened signaling pathway
- limb morphogenesis
- inner mitochondrial membrane organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrial crista
- centriole
- cilium basal body
- mitochondrion
- ciliary transition zone
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phospholipid binding